Journal of Neurodevelopmental Cognition
Quarterly Publication

Cerebellar Plasticity Changes in an Experimental Model of Autism Induced by Maternal Separation

10.52547/jncog.2023.103447
Volume 3, Issue 1
June 2023
Pages 9-15
Journal of Neurodevelopmental Cognition

Document Type : Original Article

Authors

Monireh Mansouri 1
Faeze Mashayekhi 1
Maryam Ardalan 2

1 Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran

2 Centre for Perinatal Medicine and Health, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Abstract
Autism is a neurodevelopmental disorder with a complex pathophysiology that affects different areas of the brain. Evidence over the past decade indicated a role for the cerebellum in social skills in connection with neuropathological changes. In this study, we examined cerebellar plasticity in rats that exhibited autistic-like behaviors after maternal separation (MS). We showed that autistic-like behaviors were associated with changes in cerebellar volume size. We for the first time showed the decreased volume of the cerebellum in the maternal separation animal model of autism, supporting the involvement of the cerebellum in the pathophysiology of autism.

Keywords

Autism spectrum disorders
Cerebellum
Maternal separation
  • Receive Date 17 January 2023
  • Revise Date 14 February 2023
  • Accept Date 18 February 2023

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