Journal of Neurodevelopmental Cognition
Quarterly Publication

Aptamer base nanobiosensor for stress hormone measurement

10.52547/jncog.2023.103449
Volume 3, Issue 1
June 2023
Pages 22-28
Journal of Neurodevelopmental Cognition

Document Type : Original Article

Authors

Fatemeh Mortazavi Moghadam 1
Mohammadreza Bigdeli 2
Su Ryon Shin 3

1 Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran; Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Cambridge, MA, 02139, USA

2 Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran

3 Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Cambridge, MA, 02139, USA

Abstract
Cortisol plays an important part in physiological procedures. Observing cortisol concentration as a stress indicator demonstrates the physiological mode for the diagnosis goal. The mechanism of the presented nano biosensor is LSPR and is performed based on the nucleic acid aptamer functionalized with gold nanoparticles which have specific interaction with cortisol. The interaction of aptamer particular measurement of cortisol was accomplished over the concentration from 0.05 -0.2 μg·mL-1 within 20 minutes. The detection limit is estimated to be 0.02 μg.mL-1.

Keywords

Aptamer
Silver nanoparticles
Nanobiosensor
Cortisol
  • Receive Date 03 February 2023
  • Revise Date 08 March 2023
  • Accept Date 09 March 2023

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