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Enduring Consequences of Maternal Separation on the Volume of Parvalbumin Interneurons in the Hippocampus

    Authors

    • Mozhan Parsa
    • Monireh Mansouri

    Institute for Cognitive and Brain Sciences, Shahid Beheshti University

,

Document Type : Original Article

10.48308/jncog.2025.239340.1015
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Abstract

Parvalbumin interneurons (PV-INs) are a subset of GABAergic inhibitory neurons that play a crucial role in regulating cortical and hippocampal circuits. Dysfunction of PV-INs is implicated in neurodevelopmental and psychiatric disorders. Maternal separation (MS) is a well-established rodent paradigm used to study adverse early-life experience and its long-term behavioral effects. MS has been shown to reduce PV-INs expression in different brain regions leading to disrupted cognitive behaviors. This research investigated the long-term effect of the MS on the volume of the PV-INs in the CA1 subregion of the hippocampus in rats.
Male rat pups were separated from their mothers for 3 hours daily from postnatal day (PND) 1 to PND 14. After weaning, the animals were maintained in a standard manner until adolescence. At adolescence, brain samples were extracted and the volume of the PV-INs in the CA1 area of the hippocampus was measured using the 3D stereological technique with nucleator method.
The results showed that the volume of the PV-INs in the CA1 subregion of the hippocampus in maternally separated rats was significantly smaller (p < 0.05) than the intact rats in adolescence.
This study showed that early life adverse experiences can have a persistent effect on the volume of PV-INs in the hippocampus into adolescence and suggests that MS may lead to a disruption of synaptic excitatory inhibitory balance and may be associated with symptoms related to autistic behaviors resulting from MS that have been reported in previous studies.

Keywords

  • Parvalbumin interneurons volume
  • maternal separation
  • animal model
  • neurodevelopmental disorders
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Journal of Neurodevelopmental Cognition
Volume 6, Issue 1
March 2025
Pages 94-102
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  • PDF 433.17 K
History
  • Receive Date: 04 January 2025
  • Revise Date: 27 February 2025
  • Accept Date: 03 March 2025
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How to cite
  • RIS
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  • Mendeley
  • BibTeX
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  • HARVARD
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Statistics
  • Article View: 51
  • PDF Download: 26

APA

Parsa, M. and Mansouri, M. (2025). Enduring Consequences of Maternal Separation on the Volume of Parvalbumin Interneurons in the Hippocampus. Journal of Neurodevelopmental Cognition, 6(1), 94-102. doi: 10.48308/jncog.2025.239340.1015

MLA

Parsa, M. , and Mansouri, M. . "Enduring Consequences of Maternal Separation on the Volume of Parvalbumin Interneurons in the Hippocampus", Journal of Neurodevelopmental Cognition, 6, 1, 2025, 94-102. doi: 10.48308/jncog.2025.239340.1015

HARVARD

Parsa, M., Mansouri, M. (2025). 'Enduring Consequences of Maternal Separation on the Volume of Parvalbumin Interneurons in the Hippocampus', Journal of Neurodevelopmental Cognition, 6(1), pp. 94-102. doi: 10.48308/jncog.2025.239340.1015

CHICAGO

M. Parsa and M. Mansouri, "Enduring Consequences of Maternal Separation on the Volume of Parvalbumin Interneurons in the Hippocampus," Journal of Neurodevelopmental Cognition, 6 1 (2025): 94-102, doi: 10.48308/jncog.2025.239340.1015

VANCOUVER

Parsa, M., Mansouri, M. Enduring Consequences of Maternal Separation on the Volume of Parvalbumin Interneurons in the Hippocampus. Journal of Neurodevelopmental Cognition, 2025; 6(1): 94-102. doi: 10.48308/jncog.2025.239340.1015

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